Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation
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چکیده
منابع مشابه
Selective cyclooxygenase-1 inhibition improves collateral vascular reactivity in biliary cirrhotic rats.
BACKGROUND Evidence has demonstrated that overproduction of prostacyclin (PGI2) is critical in the pathogenesis of splanchnic hyposensitivity to vasoconstrictors in the cirrhotic state. The biosynthesis of PGI2 is through cyclooxygenase (COX). This study evaluated which isoform of COX is dominant in the mechanism of collateral vascular reactivity of biliary cirrhotic rats. METHODS Three group...
متن کاملInhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.
A considerable amount of evidence collected from several different experimental systems indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in persons taking aspirin or other nonsteroidal antiinflammatory drugs on a regular basis. One property shared by all of these dru...
متن کاملEffects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine
James K. Hennan, Jinbao Huang, Terrance D. Barrett, Edward M. Driscoll, David E. Willens, Andrew M. Coronary Arteries Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Av...
متن کاملEffects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.
BACKGROUND Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inflammatory response. Prostacyclin, a product of COX-2 in vascular endothelium, has important physiological roles, such as increasing blood flow to injured tissues, reducing leukocyte adherence, and inhibiting platelet aggregation. We examined the possibility that selective COX-2 inhibition could s...
متن کاملCyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice.
AIMS The risk of adverse cardiovascular events in humans is increased with chronic use of cyclooxygenase-2 (COX-2) inhibitors. However, the role of COX-2 in animal models of cardiovascular disease has been controversial. In humans and animal models, cardiovascular disease is increased by bacterial infection of the supporting tissue of the teeth, a condition known as periodontal disease. Periodo...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2008
ISSN: 0008-6363
DOI: 10.1093/cvr/cvn287